Effects of lidocaine associated with detomidine on sedation of horses undergoing dental procedures

Samuel Jorge Ronchi, Amarildo Oliveira Lyra de Souza, Felipe Comassetto, Karen Suzane Fuchs, Luara Da Rosa, João Ricardo Kunz, Joandes Henrique Fonteque, Ademir Cassiano da Rosa, Nilson Oleskovicz

Abstract


Due to the growing increase in the dental routine in equine medicine, along with the need for patient sedation to perform this procedure, this study aimed to assess sedation by detomidine alone and/or associated with lidocaine under continuous infusion. Twenty-two horses from the dental routine of the veterinary hospital of the institution of origin were used. A jugular catheter was implanted on the day of study and animals were allocated into two distinct groups (n=11): GD, which received detomidine (20 µg kg?1), followed by continuous infusion (20 µg kg?1 h?1); and GDL, animals which received detomidine (10 µg kg?1) and lidocaine (1.3 mg kg?1), followed by continuous infusion of detomidine (10 µg kg?1 h?1) and lidocaine (25 µg kg?1 min?1). The assessed moments were as follows: M0, before catheter placement; M1, 5 minutes after bolus and beginning of infusion; M2, placement of mouth speculum; and M3, wear with an electric rasp. The assessed parameters were heart rate (HR), respiratory rate (f), systolic blood pressure (SBP), and intestinal motility. In addition to the clinical parameters, sedation was assessed by measuring head height in relation to the ground before (M0) and after treatment administration (M1) and during the dental procedure using a scale adapted for dental procedures. Statistical analysis was performed using the Shapiro-Wilk normality test by applying one-way RM ANOVA, followed by the Dunnett test for comparison in relation to M0, t-test, and Mann-Whitney test between groups (p ? 0.05). HR decreased by 20% at M2 and M3 compared to M0 only in GD, while SBP increased 35% at the same moments compared to M0 in GD and 27, 42, and 27% at M1, M2, and M3 compared to M0 in GDL, respectively. Intestinal motility decreased by 75% at all moments compared to M0 in both groups. Head height decreased by 67% in GD and 60% in GDL, with no difference between groups. Sedation scores provided by the scale did not differ between groups, with values of 1 [0–3] in GD and 3 [0–4] in GDL at M2 and 1 [0–3] in GD and 1 [1.5–3] in GDL at M3. Thus, sedation by the association between detomidine and lidocaine allowed reducing detomidine dose in half but offering similar results for dental procedures.

Keywords


Sedation.;Local anesthetic; alfa-2 agonist. Equine dentistry.

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References


Buhl, R., Ersbøll, A. K., Larsen, N. H., Eriksen, L., & Koch, J. (2007). The effects of detomidine, romifidine or acepromazine on echocardiographic measurements and cardiac function in normal horses. Veterinary Anaesthesia and Analgesia, 34(1), 1–8. https://doi.org/10.1111/j.1467-2995.2005.00269.x

Elfenbein, J. R., Sanchez, L. C., Robertson, S. A., Cole, C. A., & Sams, R. (2009). Effect of detomidine on visceral and somatic nociception and duodenal motility in conscious adult horses. Veterinary Anaesthesia and Analgesia, 36(2), 162–172. https://doi.org/10.1111/j.1467-2995.2008.00441.x

Guilhen, R. C., Cassu, R. N., Diniz, M. S., Giuffrida, R., & Duarte, R. R. (2015). A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli. Semina:Ciencias Agrarias, 36(6), 4225–4235. https://doi.org/10.5433/1679-0359.2015v36n6Supl2p4225

Kaukinen, H., Aspegrén, J., Hyyppä, S., Tamm, L., & Salonen, J. S. (2010). Bioavailability of detomidine administered sublingually to horses as an oromucosal gel. Journal of Veterinary Pharmacology and Therapeutics, 34(1), 76–81. https://doi.org/10.1111/j.1365-2885.2010.01193.x

Malone, E., Ensink, J., Turner, T., Wilson, J., Andrews, F., Keegan, K., & Lumsden, J. (2006). Intravenous Continuous Infusion of Lidocaine for Treatment of Equine Ileus. Veterinary Surgery, 35(1), 60–66. https://doi.org/10.1111/j.1532-950x.2005.00113.x

Mama, K. R., Grimsrud, K., Snell, T., & Stanley, S. (2009). Plasma concentrations, behavioural and physiological effects following intravenous and intramuscular detomidine in horses. Equine Veterinary Journal, 41(8), 772–777. https://doi.org/10.2746/042516409X421624

McCafferty, D. M., Sharkey, K. A., & Wallace, J. L. (1994). Beneficial effects of local or systemic lidocaine in experimental colitis. American Journal of Physiology, 266(4), G560–G567. https://doi.org/10.1152/ajpgi.1994.266.4.g560

Milligan, M., Beard, W., Kukanich, B., Sobering, T., & Waxman, S. (2007). The effect of lidocaine on postoperative jejunal motility in normal horses. Veterinary Surgery, 36(3), 214–220. https://doi.org/10.1111/j.1532-950X.2007.00255.x

Nannarone, S., Gialletti, R., Veschini, I., Bufalari, A., & Moriconi, F. (2007). The use of alpha-2 agonists in the equine practice: Comparison between three molecules. Veterinary Research Communications, 31(SUPPL. 1), 309–312. https://doi.org/10.1007/s11259-007-0103-7

Rohrbach, H., Korpivaara, T., & Schatzmann, U. (2009). Comparison of the effects of the alpha-2 agonists detomidine , romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses, 384–395. https://doi.org/10.1111/j.1467-2995.2009.00466.x

Roscoe, M. P. (2007). Avaliação de seis protocolos de sedação para procedimentos odontológicos em equinos. Dissertação de mestrado, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais.

Souza, J. F. F. de, Monteiro, E. R., Campagnol, D., Ramos, R. C., & Frasson, A. M. F. (2012). Evaluation of Nociception, Sedation, and Cardiorespiratory Effects of a Constant Rate Infusion of Xylazine Alone or in Combination with Lidocaine in Horses. Journal of Equine Veterinary Science, 32(6), 339–345. https://doi.org/10.1016/j.jevs.2011.11.010

Torfs, S., Delesalle, C., Dewulf, J., Devisscher, L., & Deprez, P. (2009). Risk factors for equine postoperative ileus and effectiveness of prophylactic lidocaine. Journal of Veterinary Internal Medicine, 23(3), 606–611. https://doi.org/10.1111/j.1939-1676.2009.0311.x

Valverde, A. (2010). Alpha-2 Agonists as Pain Therapy in Horses. Veterinary Clinics of North America - Equine Practice, 26(3), 515–532. https://doi.org/10.1016/j.cveq.2010.07.003

Yamashita, K., Tsubakishita, S., Futaoka, S., Ueda, I., Hamaguchi, H., Seno, T., … Muir, W. W. (2000). Cardiovascular Effects of Medetomidine, Detomidine and Xylazine in Horses. Journal of Veterinary Medical Science, 62(10), 1025–1032.

Zullian, C., Menozzi, A., Pozzoli, C., Poli, E., & Bertini, S. (2011). Effects of ?2-adrenergic drugs on small intestinal motility in the horse: An in vitro study. Veterinary Journal, 187(3), 342–346. https://doi.org/10.1016/j.tvjl.2009.12.015




DOI: http://dx.doi.org/10.5433/1679-0359.2020v41n5p1591

Semina: Ciênc. Agrár.
Londrina - PR
E-ISSN 1679-0359
DOI: 10.5433/1679-0359
E-mail: semina.agrarias@uel.br
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional