Biomarcadores cardíacos e metabólitos sanguíneos em vacas com cetose clínica
DOI:
https://doi.org/10.5433/1679-0359.2019v40n6Supl3p3525Palavras-chave:
Ácidos graxos não esterificados, ?-Hidroxibutirato, Creatina quinase MB, Sensibilidade à insulina, Troponina cardíaca I.Resumo
A intensificação do desequilíbrio energético no início da lactação é responsável pelo surgimento de distúrbios metabólicos em vacas de alta produção leiteira, em especial a cetose clínica. Este trabalho objetivou estudar o comportamento clínico, os parâmetros bioquímicos e os biomarcadores cardíacos, isoenzima MB da creatina quinase (CK-MB) e troponina cardíaca I (cTnI), de 15 vacas diagnosticadas com cetose clínica, atendidas na Clínica de Bovinos de Garanhuns, Campus da Universidade Federal Rural de Pernambuco. Nove dessas 15 vacas foram diagnosticadas com cetose primária e seis apresentaram doenças concomitantes como, deslocamento de abomaso à esquerda, metrite, pneumonia e insuficiência renal. Os sinais clínicos observados foram inespecíficos, tais como diminuição do apetite, da produção de leite e do peso. Aproximadamente 53% dos animais apresentaram sintomatologia nervosa. Para avaliação bioquímica foi selecionado um grupo de 15 vacas de alta produção, sadias e em estágio inicial de lactação, para compor o grupo controle. Os dados foram submetidos à análise de variância para comparação simultânea entre duas médias, permitindo testar a hipótese sobre as médias dos distintos grupos, além de correlações de Pearson, ao nível de 5 % de probabilidade. As variáveis, ?-Hidroxibutirato (BHB), ácidos graxos não esterificados (AGNEs), glicose, frutosamina, proteína total, albumina, creatinina, aspartato aminotransferase, creatina quinase, CK-MB e cTnI apresentaram-se mais elevadas no grupo de animais cetóticos. Os animais doentes apresentaram variação no estado glicêmico e redução da sensibilidade dos tecidos à insulina, com menor valor do índice RQUICKI-BHB, principalmente aqueles animais hiperglicêmicos. A elevação dos biomarcadores cardíacos sugere a ocorrência de lesão miocárdica associada à cetose bovina.Métricas
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Referências
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Soares, G. S. L., Ribeiro, A. C. S., Cajueiro, J. F. de P., Souto, R. J. C., Oliveira Filho, E. F. de, Soares, P. C., Mendonça, C. L. de, & Afonso, J. A. B. (2019). Biomarcadores cardíacos e metabólitos sanguíneos em vacas com cetose clínica. Semina: Ciências Agrárias, 40(6Supl3), 3525–3540. https://doi.org/10.5433/1679-0359.2019v40n6Supl3p3525
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