Linfoma multicêntrico de Células T em uma potra Crioula

Andrielli Trentim Pereira, Ana Paula Maurique Pereira, Inácio Manassi da Conceição Brandolt, Ricardo Pozzobon, Márcio Machado Costa, Bruno Leite dos Anjos, Saulo Pavarini

Abstract


A 2-year-old creole filly was referred to us for evaluation because of the clinical suspicion of infection by Streptococcus equi. It presented with progressive weight loss and increased volume of the submandibular, retropharyngeal, and precrural lymph nodes. General clinical examinations and laboratory tests revealed dehydration, anemia, leukopenia, hyperfibrinogenemia, and thrombocytopenia. The initial treatment for equine adenitis did not achieve significant results, and new hematological and biochemical tests and lymph node cytology by puncture were performed. Cytology revealed cells compatible with neoplastic lymphocytes, resulting in the suspicion of lymphoma. The animal died from general weakness and was sent for autopsy. Macroscopically, generalized lymphadenomegaly and splenomegaly were observed, with multiple nodules and tumor lesions in the splenic parenchyma. There was an irregular nodule in the medullary layer of the right kidney. The liver and lungs were slightly enlarged, with petechiae and multifocal suffusions. Histopathological evaluation of different organ specimens revealed intense proliferation of the neoplastic lymphoid cells, invading the adjacent tissues, with moderate cellular pleomorphism. Immunohistochemistry of the lymph node sections with neoplastic infiltration revealed multicentric T-cell lymphoma. In horses, cases of lymphomas are rare and should be differentiated from other causes that induce lymphadenomegaly in this species.

Keywords


Horse; Lymphadenopathy; Neoplasia; T lymphocytes.

Full Text:

PDF

References


Campos, C. G. de, Lopes, L. L., Silva, G. S. e, Cruz, R. A. S. da, Falsoni, P. C. G., Rondelli, A. L. H.,... Pescador, C. A. (2014). Linfoma de células T multicêntrico em um equino quarto de milha. Acta Scientiae Veterinariae, 42(1), 40.

Durham, A. C., Pillitteri, C. A., San Myint, M., & Valli, V. E. (2013). Two hundred three cases of equine lymphoma classified according to the world health organization (WHO) classification criteria. Veterinary Pathology, 50(1), 86-93. doi: 10.1177/0300985812451603.

Fry, M. M., & McGavin, M. D. (2009). Medula óssea células sanguíneas e sistema linfático. In M. D. McGavin, J. F. Zachary, Bases da patologia em veterinária (pp. 798-800). Rio de Janeiro: Elsevier.

Gravena, K., Rivera, G. G., Navarrete, R. A., Jark, P. C., Camacho, A. A., & Lacerda, J. C., Neto. (2018). Linfoma mediastinal em equino - relato de caso. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 70(1), 57-63. doi: 10.1590/1678-4162-9424.

Lehmbecker, A., Liebing, J., Barthel, Y., Habierski, A., Cavalleri, J., Puff, C.,... Beineke, A. (2014). Neurolymphomatosis in three horses with multicentric t-cell-rich b-cell lymphoma. Journal of Comparative Pathology, 151(2-5), 181-185. doi: 10.1016/j.jcpa.2014.04.004.

Meyer, J., Delay, J., & Bienzle, D. (2006). Clinical, laboratory, and histopathologic features of equine lymphoma. Veterinary Pathology, 43(6), 914-924. doi: 10.1354/vp.43-6-914.

Moraes, C. M. de, Vargas, A. P. C., Leite, F. P. L., Nogueira, C. E. W., & Turnes, C. G. (2009). Adenite equina, sua etiologia, diagnóstico e controle. Ciência Rural, 39(6), 1944-1952. doi: 10.1590/S0103-84782009000600050.

Morris, D. D. (2000). Doenças do sistema hemolinfático. In S. M. Reed, W. M. Bayly, Medicina interna equina (pp. 495 e 496). Rio de Janeiro: Guanabara Koogan.

Morrison, L. R., Freel, K., Henderson, I., Hahn, C., & Smith, S. H. (2008). Lymphoproliferative disease with features of lymphoma in the central nervous system of a horse. Journal of Comparative Pathology, 139(4), 256-261. doi: 10.1016/j.jcpa.2008.07.008.

Taintor, J., & Schleis, S. (2011). Equine lymphoma. Equine Veterinary Education, 23(4), 205-213. doi: 10.1111/j.2042-3292.2010.00200.x.

Ueno, T., Wada, S., Mashita, S., Kuwano, A., & Katayama, Y. (2012). Pathological findings in a case of equine T-cell lymphoma associated with ataxia. Journal of Equine Veterinary Science, 32(6), 315-319. doi: 10.1016/j.jevs.2011.11.012.

Valli, V. E. O. (2007). Hematopoietic system. In M. G. Maxie (Ed.), Jubb, Kennedy, and Palmer’s pathology of domestic animals (5nd ed., Vol. 3, pp. 107-324). Philadelphia: Saunders Elsevier.




DOI: http://dx.doi.org/10.5433/1679-0359.2020v41n2p725

Semina: Ciênc. Agrár.
Londrina - PR
E-ISSN 1679-0359
DOI: 10.5433 / 1679-0359
E-mail:  semina.agrarias@uel.br
Este obra está licenciado com uma Licença  Creative Commons Atribuição-NãoComercial 4.0 Internacional .