Arterial thromboembolism of non-cardiogenic origin in a domestic feline with ischemia and reperfusion syndrome – a case report

Gabriela da Cruz Schaefer, Tayná Mayer Veronezi, Camila Gonçalves da Luz, Letícia Gutierrez de Gutierrez, Simone Scherer, Saulo Petinatti Pavarini, Fernanda Vieira Amorim da Costa


Arterial thromboembolism (ATE) is an acute and severe clinical condition resulting from the formation of a thrombus and its accommodation in an artery, impairing the perfusion of tissues irrigated by it. In felines, it is often related to hypertrophic cardiomyopathy, but there are reports of its association with neoplasms. Ischemia and reperfusion syndrome may occur secondary to ATE and result in difficult to correct electrolyte and acid-base imbalances. The aim of the present study is to describe a case of ATE, including its clinical and laboratory findings and electrolyte and acid-base changes compatible with ischemia and reperfusion syndrome. A 14-year-old crossbreed female feline with sudden pelvic limb paralysis was treated at the Feline Medicine Service of the Federal University of Rio Grande do Sul. Clinical and laboratory alterations included hypothermia, hypotension, bradycardia, azotemia, metabolic acidosis, and hyperkalemia. The electrocardiogram indicated sinoventricular rhythm, and echocardiogram evaluation showed no alterations. Thorax radiographic evaluation revealed areas of higher radiopacity in the pulmonary fields. We opted for abdominal aorta arteriotomy as an emergency treatment for thrombus removal. The feline died in the postoperative period, and histopathological examination of lungs, mediastinal lymph nodes, and heart were performed, being compatible with pulmonary adenocarcinoma with lymph node metastasis. This study deals with a case of ATE of possible neoplastic origin, which is uncommon in cats. In this case, the patient had difficult-to-manage hemodynamic impairment, as well as electrolyte and acid-base balance disorders severe and refractory to therapy, culminating in death. The time to start treatment from the presentation of clinical signs may be determinant in therapeutic success, reducing the possible effects of reperfusion syndrome.


Pulmonary adenocarcinoma; Thromboembolic disease; Cat; Acute paralysis.

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Alwood, A. J. (2010). Management of thromboembolic disease secondary to heart disease. In K. J. Drobatz, & M. F. Costello (Eds.), Feline emergency and critical care medicine (pp. 191-197). Ames: Wiley-Blackwell.

Dibartola, S. P. (2012). Fluid, electrolyte and acid-base disorders in small animal practice. 4nd ed. St Louis: Elsevier Saunders.

Ferasin, L. (2013). Management of cardiovascular disorders. In A. Harvey, & S. Tasker (Eds.), BSAVA Manual of feline practice: a foundation manual (pp. 344-349). Quedgeley: BSAVA.

Fuentes, L. V. (2012). Arterial thromboembolism: risks, realities and a rational first-line approach. Journal of Feline Medicine and Surgery, 14(7), 459-470. doi: 10.1177/1098612X12451547

Hogan, D. F. (2016). Treatment and prevention of feline arterial thromboembolism. In S. E. Little (Ed.), August’s consultations in feline internal medicine. 7nd ed. (pp. 369-378). St Louis: Elsevier.

Hogan, D. F., Fox, P. R., Jacob, K., Keene, B., Laste, N. J., Rosenthal, S.,… Weng, H. Y. (2015). Secondary prevention of cardiogenic arterial embolism in the cat: the double-blind, randomized, positive-controlled Feline Arterial Thromboembolism; Clopidogrel vs. Aspirin Trial (FAT CAT). Journal of Veterinary Cardiology, 17, S306-S317. doi: 10.1016/j.jvc.2015.10.004

Lister, A. L., & Buchanan, J. W. (2000). Radiographic and echocardiographic measurement of the heart in obeses cat. Veterinary Radiology & Ultrasound, 41(4), 320-325. doi: 10.1111/j.1740-8261.2000.tb2080.x

Moore, K. E., Morris, N., Dhupa, N., Murtaugh, R. J., & Rusch, J. E. (2000). Retrospective study of streptokinase administration in 46 cats with arterial thromboembolism. Journal of Veterinary Emergency and Critical Care, 10(4), 245-257. doi: 10.1111/j1476-4431.2000.tb00010.x

Reimer, S. B., Kittleson, M. D., & Kyles, A. E. (2006). Use of rheolytic thrombectomy in the treatment of feline distal aortic thromboembolism. Journal of Veterinary Internal Medicine, 20(2), 290-296. doi: 10.1892/0891-6640(2006)20[290:uortit];2

Rusch, J. E. (1998). Therapy of feline hypertrophic cardiomyopathy. Veterinary Clinics of North America: Small Animal Practice, 28(6), 1459-1479. doi: 10.1016/S0195-5616(98)50132-5

Sequeira, J. F. A., Gomes, R. M., Gonzalez, M. A., & Sarmento, J. L. N. (1990). Hipercoagulabilidade neoplásica a propósito de dois casos com síndrome de Trousseau. Acta Médica Portuguesa, 3(3), 179-183.

Smith, S. A., & Tobias, A. H. (2004). Feline arterial thromboembolism: an update. Veterinary Clinics of North America: Small Animal Practice, 34(5), 1245-1271. doi: 10.1016/j.cvsm.2004.05.006

Smith, S. A., Tobias, A. H., Jacob, K. A., Fine, D. M., & Grumbles, P. L. (2003). Arterial thromboembolism in cats: acute crisis in 127 cases (1992–2001) and long-term management with low-dose aspirin in 24 cases. Journal of Veterinary Internal Medicine, 17(1), 73-83. doi:10.1892/0891-6640(2003)017<0073:aticac>;2

Takito, A. M., Silva, J. C. C. B., Bueno, V., Franco, M., & Burihan, W. (2005). Ischemic and reperfusion syndrome of hind limbs: functional and histological renal changes in rats. Medicina (Riberão Preto. Online), 38(3/4), 294-300.


Semina: Ciênc. Agrár.
Londrina - PR
E-ISSN 1679-0359
DOI: 10.5433/1679-0359
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional