Urinary infection in dogs with chronic kidney disease: aetiology and resistance

Ariane Martins Fernandes, Alessandra Tammy Hayakawa Ito de Sousa, Luciana Auxiliadora Viebrantz da Conceição, Felipe Gomes da Silva, Mayara Aparecida Araújo Cayuela, Adriane Jorge Mendonça, Arleana do Bom Parto Ferreira de Almeida, Valéria Dutra, Valeria Régia Franco Sousa


Infections of the genitourinary system are among the most frequent in the clinical routine of small animals. Treatment with the most appropriate antimicrobial therapy, according to the uropathogen susceptibility test, can avoid the spread of bacterial resistance to antimicrobials. A clinical study was performed in 32 canines, of both sexes and differing ages, who attended the Veterinary Teaching Hospital. Urine samples underwent culture, with the objective of evaluating urinary tract infection in dogs with renal disease, identifying the associated bacterial pathogens, and verifying their antimicrobial susceptibility in vitro. Urine culture was positive in 10 dogs, mostly males, with no predisposition for breed, and a mean age of 8.28 years. Most of the urinary tract infections (UTIs) were monobacterial, with the most common microorganisms being Pseudomonas sp. and Staphylococcus sp. The antimicrobials imipenem and meropenem had the best overall sensitivity profile, and ampicillin showed the highest resistance. The variation in epidemiological profiles, and susceptibility to uropathogens, reinforces the importance of the veterinarian in the prevention and control of infection, in addition to the need for further research to identify new antimicrobial agents.


Antimicrobial therapy; Canine; Nephropathy; Uropathogen.

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BARTGES, J. W. Chronic kidney disease in dogs and cats. Veterinary Clinics: Small Animal Practice, Amsterdã, v. 42, n. 4, p. 669-692, 2012. DOI: 10.1016/j.cvsm.2012.04.008

BARTGES, J. W. Diagnosis of urinary tract infections. Veterinary Clinics: Small Animal Practice, Amsterdã, v. 34, n. 4, p. 923-933, 2004.

BURTON, E. N.; COHN, L. A.; REINERO, C. N.; RINDT, H.; MOORE, S. G.; ERICSON, A. C. Characterization of the urinary microbiome in healthy dogs. PLoS One, San Francisco, v. 12, n. 5, p. 1-16, 2017. DOI: 10.1371/journal.pone.0177783

CARVALHO, V. M.; SPINOLA, T.; TAVOLARI, F.; IRINO, K.; OLIVEIRA, R. M.; RAMOS, M. C. C. Infecções do trato urinário (ITU) de cães e gatos: etiologia e resistência aos antimicrobianos. Pesquisa Veterinária Brasileira, Seropédica, v. 34, n. 1, p. 62-70, 2014. DOI: 10.1590/S0100-736X2014000100011

FELDMAN, B. V.; ZINKL, J. G.; JAIN, N. C. Schalm’s veterinary hematology. 5th ed. Ames: Wiley Blackwell Publishing, 2000. 1344 p.

GRAUER, G. F. Early detection of renal damage and disease in dogs and cats. Veterinary Clinics: Small Animal Practice, Amsterdam, v. 35, n. 3, p. 581-596, 2005.

INTERNATIONAL RENAL INTEREST SOCIETY - IRIS. Staging chronic kidney disease (CKD) 2017. Disponível em: http://www.iris-kidney.com/guidelines/staging.html. Acesso em: 07 jun 2018.

LING, G. V.; NORRIS, C. R.; FRANTI, C. E.; EISELE, P. H.; JOHNSON, D. L.; RUBY, A. L.; JANG, S. S. Interrelations of organism prevalence, specimen collection method, and host age, sex, and breed among 8,354 canine urinary tract infections (1969-1995). Journal Veterinary International Medicine, Chichester, v. 15, n. 4, p. 341-347, 2001.

MEYER, D. J.; HARVEY, J. W. Veterinary laboratory medicine: interpretation & diagnosis. 2th ed. Philadelphia: Saunders, 2004. 351 p.

OLIN, S. J.; BARTGES, J. W. Urinary tract infections. Veterinary Clinics: Small Animal Practice, Amsterdam, v. 45, n. 4, p. 721-746, 2015. DOI: 10.1016/j.cvsm.2015.02.005

PAPICH, M. G. Antibiotic treatment of resistant infections in small animals. Veterinary Clinics: Small Animal Practice, Amsterdam, v. 43, n. 5, p. 1091-1107, 2013. DOI: 10.1016/j.cvsm.2013.04.006

POLZIN, D. J. Chronic kidney disease in small animals. Veterinary Clinics: Small Animal Practice, Amsterdam, v. 41, n. 1, p. 15-30, 2011. DOI: 10.1016/j.cvsm.2010.09.004

QUINN, P. J.; CARTER, M. E.; MARKEY, B. K.; CARTER, G. R. Clinical veterinary microbioly. 2th ed. London: Mosby Year Book Europe Limited, 1994. 648 p.

THOMPSON, M. F.; LITSTER, A. L.; PLATELL, J. L.; TROT, D. J. Canine bacterial urinary tract infection: new developments in old pathogens. The Veterinary Journal, Amsterdam, v. 190, n. 1, p. 22-27, 2011. DOI: 10.1016/j.tvjl.2010.11.013

THRALL, M. A. Hematologia e bioquímica clínica veterinária. São Paulo: Roca, 2015. 582 p.

WEESE, J. S.; BLONDEAU, J. M.; BOOOTHE, D.; BREITSCHWERDT, E. B.; GUARDABASSI, L.; HILIER, A.; LLOYD, D. H.; PAPICH, M. G.; RANKIN, S. C.; TURNIDGE, J. D.; SYKES, J. E. Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases. Veterinary Medicine International, London, v. 2011, n. 263768, p. 1-9, 2011. DOI: 10.4061/2011/263768

WEESE, J. S.; BLONDEAU, J. M.; BOOOTHE, D.; GUARDABASSI, L.; GUMLEY, N.; PAPICH, M. G.; JESSEN, L. R.; LAPPIN, M.; RANKIN, S.; WESTROPP, J. L.; SYKES, J. E. International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. The Veterinary Journal, Amsterdam, v. 247, n. 2019, p. 8-25, 2019. DOI: 10.1016/j.tvjl.2019.02.008 1090-0233

WHITE, J. D.; STEVENSON, M.; MALIK, R.; SNOW, D.; NORRIS, J. M. Urinary tract infections in cats with chronic kidney disease. Journal of Feline Medical Surgery, London, v.15, n. 6, p. 459-65, 2013. DOI: 10.1177/1098612X12469522

WONG, C.; EPSTEIN, S. E.; WESTROPP, J. L. Antimicrobial susceptibility patterns in urinary tract infections in dogs (2010-2013). Journal Veterinary International Medicine, Chichester, v. 29, n. 4, p. 1045-1052, 2015. DOI: 10.1111/jvim.13571

DOI: http://dx.doi.org/10.5433/1679-0359.2019v40n6Supl3p3741

Semina: Ciênc. Agrár.
Londrina - PR
E-ISSN 1679-0359
DOI: 10.5433 / 1679-0359
E-mail:  semina.agrarias@uel.br
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