Correlation between Rubino's reaction and soluble sheep erythrocyte-receptors in Hansen's patients

Claudete Serrano Astolfi Ferreira, Doura Abdul Hamid, Daysi Regina Train, Emerson José Venâncio, Eiko Nakagawa Itano

Resumo


This study investigated the correlation between either (actors or molecules that interact with formolate sheep's erythrocytes (Rubino's reaction) and T lymphocytes soluble receptors for sheep erythrocytes (Rs2) present at a high level in the serum of Hansen's patients. The analysis of fractions obtained by chromatography on Sephadex G-200 showed positive Rubino's reaction in the fraction that correspond to Rs2 with more than 150 kDa, detected by a specific anti-soluble receptor. Additionally, the level of the soluble receptor present in the serum of Hansen's patients, showing positive or negative Rubino's reaction, was determinated by immunodiffusion (Mancini). The result demonstrated no statistical difference between serum soluble receptor level in positive (7.3 mm) or negative (7.3 mm) Rubino's reactions, giving evidence that the high molecular weight E-soluble receptor is not responsible for Rubino's reactions.



Palavras-chave


Rubino's reaction; Leprosy; E-receptors; CD2.

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DOI: http://dx.doi.org/10.5433/1679-0367.1994v15n2p117

Direitos autorais 2016 Semina: Ciências Biológicas e da Saúde

Licença Creative Commons
Esta obra está licenciada sob uma licença Creative Commons Atribuição - NãoComercial 4.0 Internacional.

Semina: Ciênc. Biol. Saúde

email: seminabio@uel.br

Londrina - PR
ISSN Print: 1676-5435

EISSN: 1679-0367