Composting of swine waste in the treatment of veterinary drug residues

Robson Evaldo Gehlen Bohrer, Elvis Carissimi, Diosnel Antonio Rodriguez Lopez, Delmira Beatriz Wolff, Danni Maisa da Silva, Osmar Damian Prestes

Abstract


The increasing need for animal protein has exerted pressures on the current animal production system. One of the alternatives found by producers to improve animal performance has been the use of veterinary drugs, especially antibiotics. However, its indiscriminate use can be a risk to the environmental balance of the producing locations since Brazil has approximately 42 million pigs. With this herd, pig farming represents a great potential for generating environmental impacts. As an alternative use of the large volume of liquid pig manure generated, many producers have been using this slurry in the soil as a bio fertilizer. Residues of veterinary drugs are capable of accumulation with environmental matrices and leach into water resources. In this sense, it is mandatory to dedicate more efforts on the study of techniques and processes for the treatment of organic effluents contaminated by veterinary drugs. Low-cost and environmentally friendly alternative treatment systems are necessary, in order to minimize the entry of these contaminants into the environment. Therefore, the composting process, defined as aerobic microbial decomposition process of organic matter, can be an alternative for treating the effluents contaminated by veterinary drugs. This review to aims to create awareness in the academic community regarding the veterinary drug residues and their contamination potential in different environmental matrices, as well as evaluating the composting process as a technique to minimize the impacts of the swine activity waste on the environment.

Keywords


Antibiotics; Contamination; Environment; Treatment; Accumulation.

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References


AMÉRICO, J. H. P.; ISIQUE, W. D.; MINILLO, A.; CARVALHO, S. L.; TORRES, N. H. Fármacos em uma estação de tratamento de esgoto na região Centro-oeste do Brasil e os riscos aos recursos hídricos. Revista Brasileira de Recursos Hídricos, Porto Alegre, v. 17, n. 3, p. 61-67, 2012. DOI: 10.21168/rbrh.v17n3.p61-67

ARAUJO, K.; NEVES, M.; SÁ, M.; SILVA, L.; BRITO, N. Fármacos residuais: um problema de caráter ambiental. In: CONGRESSO DE PESQUISA E INOVAÇÃO DA REDE NORTE NORDESTE DE EDUCAÇÃO TECNOLÓGICA, Maceió, 2010. Anais... Maceió: Instituto Federal de Alagoas, 2010. p. 1-8.

ARCHUNDIA, D.; DUWIG, C.; LEHEMBRE, F.; CHIRON, S.; MOREL, M. C.; PRADO, B.; BOURDAT-DESCHAMPS, M.; VINCE, E.; AVILES, G. F.; MARTINS, J. M. F. Antibiotic pollution in the Katari subcatchment of the Titicaca Lake: major transformation products and occurrence of resistance genes. Science of The Total Environment, Sonora, México, v. 576, n. 3, p. 671-682, 2017. DOI: 10.1016/j.scitotenv.2016.10.129

ASSOCIAÇÃO BRASILEIRA DE CRIADORES DE SUÍNOS - ABCS. ABCS e representantes de agroindústrias se reúnem para discutir Projeto de Lei sobre produção integrada. Brasília: SIG, 2014. Disponível em: http://www.abcs.org.br/informativo-abcs.Janeiro de 2014. Acesso em: 22 jan. 2014.

BAO, Y.; ZHOU, Q.; GUAN, L.; WANG, Y. Depletion of chlortetracycline during composting of aged and spiked manures. Waste Management, Tianjin, v. 29, n. 4, p. 1416-1423, 2009. DOI: 10.1016/j.wasman.2008.08.022

BARBOSA, M. O.; MOREIRA, N. F.; RIBEIRO, A. R.; PEREIRA, M. F.; SILVA, A. M. Occurrence and removal of organic micropollutants: an overview of the watch list of EU Decision 2015/495. Water Research, Porto, v. 94, n. 7, p. 257-279, 2016. DOI: 10.1016/j.watres.2016.02.047

BEN, W.; WANG, J.; PAN, X.; QIANG, Z. Dissemination of antibiotic resistance genes and their potential removal by on-farm treatment processes in nine swine feedlots in Shandong Province, China. Chemosphere, Beijing, v. 167, n. 2, p. 262-268, 2017. DOI: 10.1016/j.chemosphere.2016.10.013

BOLEDA, M. R.; GALCERAN, M. T.; VENTURA, F. Validation and uncertainty estimation of a multiresidue method for pharmaceuticals in surface and treated waters by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, Barcelona, v. 1286, n. 15, p. 146-158, 2013. DOI: 10.1016/j.chroma.2013.02.077

BONDARCZUK, K.; MARKOWICZ, A.; PIOTROWSKA-SEGET, Z. The urgent need for risk assessment on the antibiotic resistance spread via sewage sludge land application. Environment International, Katowice, v. 87, n. 2, p. 49-55, 2016. DOI: 10.1016/j.envint.2015.11.011

BRASIL. Portaria de consolidação de nº 4 de 28 de setembro de 2017 do Ministério da Saúde. Dispõe sobre os procedimentos de controle e de vigilância da qualidade da água para consumo humano e seu padrão de potabilidade. Brasília: Ministério da Saúde, 2017. 350 p. Disponível em: http://bvsms.saude.gov.br/bvs/ saudelegis/gm/2017/prc0005_03_10_2017.html. Acesso em: 14 jun. 2019

BRASIL. Resolução do CONAMA n° 357, de 18 de março de 2005. Dispõe sobre a classificação dos corpos de água e diretrizes ambientais para o seu enquadramento, bem como estabelece as condições e padrões de lançamento de efluentes, e dá outras providências. Brasília: Congresso Nacional, 2005. 27 p. Disponível em: http://www.mma.gov.br/port/conama/res/res05/res35705.pdf. Acesso em: 10 fev. 2017.

BRASIL. Resolução do CONAMA n° 420, de 28 de dezembro de 2009. Dispõe sobre critérios e valores orientadores de qualidade do solo quanto à presença de substâncias químicas e estabelece diretrizes para o gerenciamento ambiental de áreas contaminadas por essas substâncias em decorrência de atividades antrópicas. Brasília: Congresso Nacional, 2009. 20 p. Disponível em: http://www.mma.gov.br/port/conama/ legiabre.cfm?codlegi=620. Acesso em: 20 fev. 2017.

BRASIL. Resolução do CONAMA nº. 430. Dispõe sobre as condições e padrões de lançamento de efluentes, complementa e altera a Resolução nº 357, de 17 de março de 2005, do Conselho Nacional do Meio Ambiente, CONAMA. Brasília: Congresso Nacional, 2011. 9 p. Disponível em: http://www.mma.gov. br/port/conama/legiabre.cfm?codlegi=646. Acesso em: 15 nov. 2016.

CADONÁ, E. A.; SOUZA, E. L.; GUERRA, D.; BOHRER, R. E. G. Utilização de adubação orgânica com dejetos de suínos e contaminação de água e de solo por coliformes. Ciência e Natura, Santa Maria, v. 38, n. 3, p. 1601-1609, 2016. DOI: 10.5902/2179460X22410

CARVALHO, E. V.; FERREIRA, E.; MUCINI, L.; SANTOS, C. L. Aspectos legais e toxicológicos do descarte de medicamentos. Revista Brasileira de Toxicologia, São Paulo, v. 22, n. 1-2, p. 1-8, 2009.

CENTNER, T. J. Recent government regulations in the United States seek to ensure the effectiveness of antibiotics by limiting their agricultural use. Environment International, Athens, v. 94, n.7, p. 1-7, 2016. DOI: 10.1016/j.envint.2016.04.018

CHEN, C.; RAY, P.; KNOWLTON, K. F.; PRUDEN, A.; XIA, K. Effect of composting and soil type on dissipation of veterinary antibiotics in land-applied manures. Chemosphere, Blacksburg, v. 196, n. 6, p. 270-279, 2018. DOI: 10.1016/j.chemosphere.2017.12.161

CHENG, D.; FENG, Y.; LIU, Y.; XUE, J.; LI, Z. Dynamics of oxytetracycline, sulfamerazine, and ciprofloxacin and related antibiotic resistance genes during swine manure composting. Journal of Environmental Management, Beijing, v. 230, n. 2, p. 102-109, 2019. DOI: 10.1016/j.jenvman.2018.09.074

CHENG, W.; LI, J.; WU, Y.; XU, L.; SU, C.; QIAN, Y.; ZHU, Y.-G.; CHEN, H. Behavior of antibiotics and antibiotic resistance genes in eco-agricultural system: A case study. Journal of Hazardous Materials, Hangzhou, v. 304, n. 4, p. 18-25, 2016. DOI: 10.1016/j.jhazmat.2015.10.037

DAGHRIR, R.; DROGUI, P. Tetracycline antibiotics in the environment: a review. Environmental Chemistry Letters, Quebec, v. 11, n. 3, p. 209-227, 2013. DOI: 10.1007/s10311-013-0404-8

DU, L.; LIU, W. Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review. Agronomy for Sustainable Development, Beijing, v. 32, n. 2, p. 309-327, 2012. DOI: 10.1007/s13593-011-0062-9

EZZARIAI, A.; HAFIDI, M.; KHADRA, A.; AEMIG, Q.; EL FELS, L.; BARRET, M.; MERLINA, G.; PATUREAU, D.; PINELLI, E. Human and veterinary antibiotics during composting of sludge or manure: Global perspectives on persistence, degradation, and resistance genes. Journal of Hazardous Materials, Marrakech, v. 359, n. 18, p. 465-481, 2018. DOI: 10.1016/j.jhazmat.2018.07.092

FOOD AND DRUG ADMINISTRATION - FDA. The Green Book - FDA, approved products. food and drug administration. Rockville: FDA, 2017. Disponível em: http://www.accessdata.fda.gov/scripts/ animaldrugsatfda.2012. Acesso em: 20 fev. 2017.

GBYLIK-SIKORSKA, M.; POSYNIAK, A.; SNIEGOCKI, T.; ZMUDZKI, J. Chemosphere liquid chromatography - tandem mass spectrometry multiclass method for the determination of antibiotics residues in water samples from water supply systems in food-producing animal farms. Chemosphere, Pulawy, v. 119, n. 2, p. 8-15, 2015. DOI: 10.1016/j.chemosphere.2014.04.105

GELBAND, H.; MILLER-PETRIE, M.; PANT, S.; GANDRA, S.; LEVINSON, J.; BARTER, D.; WHITE, A.; LAXMINARAYAN, R. State of the world’s antibiotics. Washington: Center for Disease Dynamics, Economics & Policy, CDDEP, 2015. 84 p.

GONZALEZ RONQUILLO, M.; HERNANDEZ, J. C. A. Antibiotic and synthetic growth promoters in animal diets: review of impact and analytical methods. Food Control, Toluca, v. 72, Part. b, p. 255-267, 2017. DOI: 10.1016/j.foodcont.2016.03.001

GUO, C.; WANG, M.; XIAO, H.; WANG, F.; PAN, W.; LIAO, X.; LIU, Y. Development of a modified QuEChERS method for the determination of veterinary antibiotics in swine manure by liquid chromatography tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Guangzhou, v. 1027, n. 19, p. 110-118, 2016. DOI: 10.1016/j.jchromb.2016.05.034

HAMSCHER, G.; PAWELZICK, T. G.; HOPER, H. N. Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure. Environmental Toxicology and Chemistry, Hannover, v. 24, n. 4, p. 861-868, 2005. DOI: 10.1897/04-182R.1

HE, L. Y.; YING, G.-G.; LIU, Y.-S.; SU, H.-C.; CHEN, J.; LIU, S.-S.; ZHAO, J.-L. Discharge of swine wastes risks water quality and food safety: antibiotics and antibiotic resistance genes from swine sources to the receiving environments. Environment International, Guangzhou, v. 92-93, n. 6, p. 210-219, 2016. DOI: 10.1016/j.envint.2016.03.023

HO, Y. B.; ZAKARIA, M. P.; LATIF, P. A.; SAARI, N. Degradation of veterinary antibiotics and hormone during broiler manure composting. Bioresource Technology, Selangor, v. 131, n. 4, p. 476-484, 2013. DOI: 10.1016/j.biortech.2012.12.194

HU, J.; ZHOU, J.; ZHOU, S.; WU, P.; TSANG, Y. F. Occurrence and fate of antibiotics in a wastewater treatment plant and their biological effects on receiving waters in Guizhou. Process Safety and Environmental Protection, Guiyang, v. 113, n. 1, p. 483-490, 2018. DOI: 10.1016/j.psep.2017.12.003

IDE, A. H.; AHMAD, S. M.; NENG, N. R.; NOGUEIRA, J. M. F. Enhancement for trace analysis of sulfonamide antibiotics in water matrices using bar adsorptive microextraction (BA?E). Journal of Pharmaceutical and Biomedical Analysis, Lisboa, v. 129, n.12, p. 593-599, 2016. DOI: 10.1016/j.jpba.2016.07.022

INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA - IBGE. Produção da Pecuária Municipal. Rio de Janeiro: IBGE, 2015. v. 43, 49 p. Disponível em: http://biblioteca.ibge.gov.br/index.php/biblioteca-catalogo?view=detalhes&id=784. Acesso em: 14 jan. 2016.

KIM, K.; OWENS, G.; OK, Y. S.; PARK, W. K.; LEE, D. B.;. KNON, S. I. Decline in extractable antibiotics in manure-based composts during composting. Waste Management, Kyounggi-do, v. 32, n. 1, p. 110-116, 2012. DOI: 10.1016/j.wasman.2011.07.026

KIM, Y.; LEE, K. B.; CHOI, K. Effect of runoff discharge on the environmental levels of 13 veterinary antibiotics: a case study of Han River and Kyungahn Stream, South Korea. Marine Pollution Bulletin, Seoul, v. 107, n. 1, p. 1-8, 2015. DOI: 10.1016/j.marpolbul.2016.03.011

KOBA, O.; GOLOVKO, O.; KODESOVÁ, R.; FÉR, M.; GRABIC, R. Antibiotics degradation in soil: a case of clindamycin, trimethoprim, sulfamethoxazole and their transformation products. Environmental Pollution, Vod?any, v. 220, part B, p. 1251-1263, 2016. DOI: 10.1016/j.envpol.2016.11.007

LI, C.; CHEN, J.; WANG, J.; MA, Z.; HAN, P.; LUAN.; LU, A. Occurrence of antibiotics in soils and manures from greenhouse vegetable production bases of Beijing, China and an associated risk assessment. Science of the Total Environment, Beijing, v. 521-522, n. 19, p. 101-107, 2015. DOI: 10.1016/j.scitotenv.2015.03.070

LI, W.; SHI, Y.; GAO, L.; LIU, J.; CAI, Y. Occurrence of antibiotics in water, sediments , aquatic plants, and animals from Baiyangdian Lake in North China. Chemosphere, Beijing, v. 89, n. 11, p. 1307-1315, 2012. DOI: 10.1016/j.chemosphere.2012.05.079

LIU, B.; LI, Y.; ZHANG, X.; FENG, C.; GAO, M.; SHEN, Q. Effects of composting process on the dissipation of extractable sulfonamides in swine manure. Bioresource Technology, Beijing, v. 175, n. 1, p. 284-290, 2015. DOI: 10.1016/j.cjche.2017.06.020

LIU, L.; LIU, C.; ZHENG, J.; JUANG, X.; WANG, Z.; LIU, W.; ZHU, G. Elimination of veterinary antibiotics and antibiotic resistance genes from swine wastewater in the vertical flow constructed wetlands. Chemosphere, Xiamen, v. 91, n. 8, p. 1088-1093, 2013. DOI: 10.1016/j.chemosphere.2013.01.007

LÓPEZ-SERNA, R.; PÉREZ, S.; GINEBREDA, A.; PETROVIC, M.; BARCELÓ, D. Fully automated determination of 74 pharmaceuticals in environmental and waste by online solid phase extradition-liquid chromatography-electrospray tandem mass spectrometry. Talanta, London, v. 83, n. 2, p. 410-424, 2010. DOI: 10.1016/j.chroma.2012.06.078

LUCAS, D.; BADIA-FABREGAT, M.; CAMINAL, G.; RODRIGUEZ-MOZAZ, S.; BALCAZAR, J. L.; BARCELO, D. Fungal treatment for the removal of antibiotics and antibiotic resistance genes in veterinary hospital wastewater. Chemosphere, Girona, v. 152, n. 10, p. 301-308, 2016. DOI: 10.1016/j.chemosphere.2016.02.113

MARTÍNEZ-CARBALLO, E.; GONZÁLEZ-BARREIRO, C.; SCHARF, S.; GANS, O. Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria. Environmental Pollution, Spittelauer Lande, v. 148, n. 2, p. 570-579, 2007. DOI: 10.1016/j.envpol.2006.11.035

MELO, F. V.; BROWN, G. G.; CONSTANTINO, R.; LOUZADA, J. N. C.; LUIZÃO, F. J.; MORAIS, J. W.; ZANETTI, R. A importância da meso e macrofauna do solo na fertilidade e como biondicadores. Colombo: Boletim Informativo da SBCS, jan./abr. 2009. 3 p. Disponível em: http://sbcs.solos.ufv.br/solos/ boletins/biologia%20macrofauna.pdf. Acesso em: 10 fev. 2017.

MINISTÉRIO DA AGRICULTURA, PECUÁRIA E ABASTECIMENTO - MAPA. Brasil. Brasília: MAPA, 2015. Disponível em: http://www.agricultura.gov.br/animal/especies/suinos. Acesso em: 18 out. 2015.

MITCHELL, S. M.; ULLMAN, J. L.; BARY, A.; COGGER, C. G.; TEEL, A. L.; WATTS, R. J. Antibiotic degradation during thermophilic composting. Water Air Soil Pollut, Pullman, v. 13, n. 226, p. 1-12, 2015. DOI: 10.2134/jeq2015.05.0256

MORTIER, N.; VELGHE, F.; VERSTICHEL, S. Organic recycling of agricultural digestion. In: POLTRONIERI, P.; D’URSO, O. F. (Ed.). Biotransformation of agricultural waste and by-products. Amsterdam. The Food, Feed, Fibre, Fuel (4F) Economy, Elsevier Radarweg 29, PO Box 211, 1000 AE Amsterdam, Netherlands, 2016. p. 69-124.

NGUYEN, T. K. X.; THAYANUKUL, P.; PINYANKONG, O.; SUTTINUN, O. Tiamulin removal by wood-rot fungi isolated from swine farms and role of ligninolytic enzymes. International Biodeterioration & Biodegradation, Bangkok, v. 116, n. 1, p. 147-155, 2017. DOI: 10.1016/j.ibiod.2016.10.010

OLIVEIRA, P. A. V.; HIRAGASHI, M. M. Unidade de compostagem para o tratamento dos dejetos de suínos. Concórdia: EMBRAPA, 2006. n. 1, 39 p. (Documento, 114).

OMAR, F. N.; XIANG, L. Y.; LIE, L. Y.; DZULKRNAIN, C. A.; MOHAMMED, M. A. P.; BAHARUDDIN, A. S. Investigation of physico-chemical properties and microbial community during poultry manure co-composting process. JES, Selangor, v. 28, n. 1, p. 81-94, 2014. DOI: 10.1016/j.jes.2014.07.023

PACHECO-SILVA, É.; SOUZA, J. R.; CALDAS, E. D. Resíduos de medicamentos veterinários em leite e ovos. Quimica Nova, Brasília, v. 37, n. 1, p. 111-122, 2014. DOI: 10.1590/S0100-40422014000100020

PETRIE, B.; YOUDAN, J.; BARDEN, R.; KASPRZYK-HORDEN, B. Multi-residue analysis of 90 emerging contaminants in liquid and solid environmental matrices by ultra-high-performance liquid chromatography tandem mass spectrometry. Journal of Chromatography A, Bath, v. 1431, n. 4, p. 64-78, 2016. DOI: 10.1016/j.chroma.2015.12.036

PINHEIRO, A.; ALBANO, R. M. R.; ALVES, T. C.; KAUFAMANN, V.; SILVA, M. R. Veterinary antibiotics and hormones in water from application of pig slurry to soil. Agricultural Water Management, Blumenau, v. 129, n. 375, p. 1-8, 2013. DOI: 10.1016/j.agwat.2013.06.019

PRESTES, O. D.; MARTINS, M. L.; FRIGGI, C. A.; MUNARETTO, J. S.; ADAIME, M. B.; ZANELLA, R. O estado da arte na determinação de resíduos de medicamentos veterinários em alimentos de origem animal empregando técnicas cromatográficas acopladas à espectrometria de massas. Quimica Nova, Santa Maria, v. 36, n. 5, p. 697-710, 2013. DOI: 10.1590/S0100-40422013000500015

PULICHARLA, R.; BRAR, S. K.; ROUISSI, T.; AUGER, S.; DROGUI, P.; VERMA, M.; SURAMPALLI, R. Y. Degradation of chlortetracycline in wastewater sludge by ultrasonication, Fenton oxidation, and ferro-sonication. Ultrasonics Sonochemistry, Québec, v. 34, n. 1, p. 332-342, 2017. DOI: 10.1016/j.ultsonch.2016.05.042

QIAN, M.; WU, H.; WANG, J.; ZHANG, H.; ZHANG, Z.; ZHANG, Y.; LIN, H.; MA, J. Occurrence of trace elements and antibiotics in manure-based fertilizers from the Zhejiang Province of China. Science of the Total Environment, Hangzhou, v. 559, n. 20, p. 174-181, 2016a. DOI: 10.1016/j.scitotenv.2016.03.123

QIAN, X.; SUN, W.; GU, J.; WANG, X.-J.; SUN, J.-J.; YIN, Y.-N.; DUAN, M.-L. Variable effects of oxytetracycline on antibiotic resistance gene abundance and the bacterial community during aerobic composting of cow manure. Journal of Hazardous Materials, Yangling, v. 315, n. 15, p. 61-69, 2016b. DOI:10.1016/j.jhazmat.2016.05.002

REGITANO, J. B.; LEAL, R. M. P. Comportamento e impacto ambiental de antibióticos usados na produção animal Brasileira. Revista Brasileira de Ciencia do Solo, Piracicaba, v. 34, n. 3, p. 601-616, 2010. DOI: 10.1590/S0100-06832010000300002

REIS, E. O.; FOUREAUX, A. F. S.; RODRIGUES, J. S.; MOREIRA, V. R.; LEBRON, Y. A.; SANTOS, L. V.; AMARAL, M. C. S.; LANGE, L. C. Occurrence, removal and seasonal variation of pharmaceuticals in Brasilian drinking water treatment plants. Environmental Pollution, Belo Horizonte, v. 250, n. 6, p. 773-781, 2019. DOI: 10.1016/j.envpol.2019.04.102

RHOUMA, M.; BEAUDRY, F.; LETELLIER, A. Resistance to colistin: what is the fate for this antibiotic in pig production? International Journal of Antimicrobial Agents, Saint-Hyacinthe, v. 48, n. 2, p. 119-126, 2016. DOI: 10.1016/j.ijantimicag.2016.04.008

RIBEIRO, A. R.; NUNES, O. C.; PEREIRA, M. F. R.; SILVA, A. M. T. An overview on the advanced oxidation processes applied for the treatment of water pollutants de fi ned in the recently launched Directive 2013 / 39 / EU. Environment International, Porto, v. 75, n. 2, p. 33-51, 2015. DOI: 10.1016/j.envint.2014.10.027

RICO, A.; OLIVEIRA, R.; McDONOUGH, S.; MATSER, A.; KHATIKARN, J.; SATAPORNAVANIT, K.; NOGUEIRA, A. J. A.; SOARES, A. M. V. M.; DOMINGUES, I.; BRINK, P. J. Use, fate and ecological risks of antibiotics applied in tilapia cage farming in Thailand. Environmental Pollution, Wageningen, v. 191, n. 7, p. 8-16, 2014. DOI: 10.1016/j.envpol.2014.04.002

RIO GRANDE DO SUL. Secretaria do Ambiente e Desenvolvimento Sustentável - Conselho Estadual do Meio Ambiente - Resolução CONSEMA N º 355, de 13 de junho de 2017. Dispõe sobre os critérios e padrões de emissão de efluentes líquidos para as fontes geradoras que lancem seus efluentes em águas superficiais no Estado do Rio Grande do Sul. Porto Alegre: SEMA, 2017. Disponível em: http://www.sema.rs.gov.br/resolucoes. Acesso em: 1 set. 2017.

RODRIGUES-SILVA, C.; MANIERO, M. G.; GUIMARÃES, J. R. Avaliação da atividade antimicrobiana de soluções de flumequina submetidas aos processos eletroquímico e foto-eletroquímico. Quimica Nova, Campinas, v. 37, n. 5, p. 789-795, 2014. DOI: 10.5935/0100-4042.20140127

SEGURA, P. A.; TAKADA, H.; CORREA, J. A.; SAADI, K.; KOIKE, T.; ONWONA-AGYENAN, S.; OFOSU-ANIM, J.; SABI, E. B.; WASONGA, O. V.; MAGHALU, J. M.; SANTOS, A. M.; NEWMAN, B.; WEERTS, S.; YARGEAU, V. Global occurrence of anti-infectives in contaminated surface waters: impact of income inequality between countries. Environment International, Sherbrooke, v. 80, n. 6, p. 89-97, 2015. DOI: 10.1016/j.envint.2015.04.001

SILVA, C. G. A.; COLLINS, C. H. Aplicações de cromatografia líquida de alta eficiência para o estudo de poluentes orgânicos emergentes. Química Nova, Campinas, v. 34, n. 4, p. 665-676, 2011. DOI:org/10.1590/S0100-40422011000400020

SOLLIEC, M.; ROY-LACHAPELLE, A.; GASSE, M.-O.; COTÉ, C.; GÉNÉREUX, M.; SAUVÉ, S. Fractionation and analysis of veterinary antibiotics and their related degradation products in agricultural soils and drainage waters following swine manure amendment. Science of the Total Environment, Montréal, v. 543, n. 4, p. 524-535, 2016. DOI: 10.1016/j.scitotenv.2015.11.061

SOSA-FERRERA, Z.; MAHUGO-SANTANA, C.; SANTANA-RODRÍGUEZ, J. J. Analytical methodologies for the determination of endocrine disrupting compounds in biological and environmental samples. BioMed Research International, Las Palmas de Gran Canaria, v. 2013, n. 3, p. 674-838, 2013. DOI: 10.1155/2013/674838

SUI, Q.; ZHANG, J.; CHEN, M.; TONG, J.; WANG, R.; WEI, Y. Distribution of antibiotic resistance genes (ARGs) in anaerobic digestion and land application of swine wastewater. Environmental Pollution, Beijing, v. 213, n. 5, p. 751-759, 2016. DOI: 10.1016/j.envpol.2016.03.038

TASHO, R. P.; CHO, J. Y. Veterinary antibiotics in animal waste, its distribution in soil and uptake by plants: a review. Science of the Total Environment, Jeollabuk-do, v. 563-564, n. 3, p. 366-376, 2016. DOI: 10.1016/j.scitotenv.2016.04.140

VAN BOECKEL, T. P.; BROWER, C.; GILBERT, M.; GRENFELL, B. T.; LEVIN, S. A.; ROBINSON, T. P.; TEILLANT, A.; LAXMINARAYAN, R. Global trends in antimicrobial use in food animals. Proceedings of the National Academy of Sciences of the United States of America, Princeton, v. 112, n. 18, p. 5649-5645, 2015. DOI: 10.1073/pnas.1503141112

YANG, C. W.; HSIAO, W. C.; CHANG, B. V. Biodegradation of sulfonamide antibiotics in sludge. Chemosphere, Taipei, v. 150, n. 8, p. 559-565, 2016. DOI: 10.1016/j.chemosphere.2016.02.064

YASSER, M. A.; SANG, S. L.; SUNG-CHUL, K.; JAE, E. Y.; YONG, S. O. Novel approaches to monitoringand remediation of veterinary antibiotics in soil and water: a review. Korean Journal of Environmental Agriculture, Chuncheon, v. 29, n. 4, p. 315-327, 2010. DOI: 10.5338/KJEA.2010.29.4.315

WANG, J.; BEN, W.; YANG, M.; ZHANG, Y.; QIANG, Z. Dissemination of veterinary antibiotics and corresponding resistance genes from a concentrated swine feedlot along the waste treatment paths. Environment International, Beijing, v. 92-93, n. 6, p. 317-323, 2016a. DOI: 10.1016/j.envint.2016.04.020

WANG, R.; CHEN, M.; FENG, F.; ZHANG, J.; SUI, Q.; TONG, J.; WEI, Y.; WEI, D. Effect of red mud addition on tetracycline and copper resistance genes and microbial community during the full scale swine manure composting. Bioresource Technology, Beijing, v. 216, n. 17, p. 1049-1057, 2016b. DOI: 10.1016/j.biortech.2016.06.012

WEI, R.; GE, F.; ZHANG, L.; HOU, X.; CAO, Y.; GONG, L.; CHEN, M.; WANG, R.; BAO, E. Occurrence of 13 veterinary drugs in animal manure-amended soils in Eastern China. Chemosphere, Nanjing, v. 144, n. 2, p. 2377-2383, 2016. DOI: 10.1016/j.chemosphere.2015.10.126

WU, J.; ZHAO, Y.; YANG, T.; ZHANG, X.; XIE, X.; CUI, H.; WEI, Z. Effect of precursors combined with bacteria communities on the formation of humic substances during different materials composting. Bioresource Technology, Harbin, v. 226, n. 4, p. 191-199, 2017. DOI: 10.1016/j.biortech.2016.12.031

WU, M.-H.; QUE, C.-J.; XU, G.; SUN, Y.-F.; MA, J.; XU, H.; SUN, R.; TANG, L. Occurrence, fate and interrelation of selected antibiotics in sewage treatment plants and their receiving surface water. Ecotoxicology and Environmental Safety, Shanghai, v. 132, n. 10, p. 132-139, 2016. DOI: 10.1016/j.ecoenv.2016.06.006

ZHANG, M.; HE, L. Y.; LIU, Y. S.; ZHAO, J. L.; LIU, W. R.; ZHANG, J. N.; CHEN, J.; HE, L. K.; ZHANG, Q. Q.; YING, G. G. Fate of veterinary antibiotics during animal manure composting. Science of the Total Environment, Beijing, v. 650, n. 2, p. 1363-1370, 2019. DOI: 10.1016/j.scitotenv.2018.09.147

ZHANG, Y.; LI, H.; GU, J.; QIAN, X.; YIN, Y.; LI, Y.; ZHANG, R.; WANG, X. Residues and risks of veterinary antibiotics in protected vegetable soils following application of different manures. Chemosphere, Beijing, v. 152, n. 10, p. 229-237, 2016a. DOI: 10.1016/j.chemosphere.2016.02.111

ZHANG, Y.; SALLACH, J. B.; HODGES, L.; SNOW, D. D.; BARTELT-HUNT, S. L.; ESKRIDGE, K. M.; LI, X. Effects of soil texture and drought stress on the uptake of antibiotics and the internalization of Salmonella in lettuce following wastewater irrigation. Environmental Pollution, Lincoln, v. 208, n. 1, p. 523-531, 2016b. DOI: 10.1016/j.envpol.2015.10.025




DOI: http://dx.doi.org/10.5433/1679-0359.2019v40n6p2813

Semina: Ciênc. Agrár.
Londrina - PR
E-ISSN 1679-0359
DOI: 10.5433/1679-0359
E-mail: semina.agrarias@uel.br
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional