Pemphigus foliaceus in a sheep

Aline Antas Cordeiro Cavalcanti, Ana Claudia Campos, Aline Guedes Mamede Moraes, Clarice Ricardo de Macêdo Pessoa, Franklin Riet-Correa, Marcia Almeida Melo, Edisio Oliveira Azevedo

Abstract


Pemphigus foliaceus (PF) is an autoimmune disease of the skin and is the most common form of pemphigus in domestic animals. This work reports a case of pemphigus foliaceus in a Santa Inês hair sheep. The ewe presented with multifocal bilateral crusted alopecic dermatitis affecting the chest, abdomen, and pelvic and thoracic limbs. Parakeratotic hyperkeratosis and acanthosis, in addition to subcorneal pustules, were observed histologically, and acantholytic cells and neutrophils were observed within the pustules. In the superficial and deep dermal tissues, there was intense eosinophilic infiltration and the presence of rare macrophages. These microscopic findings were characteristic of PF, and treatment with dexamethasone was ineffective. This disease is rare in sheep, and this is the first case report to be published in Brazil.

Keywords


Pemphigus foliaceus; Sheep; Skin.

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References


BRENNER, D. J.; STOKKING, L.; DONOVAN, T. A.; LAMBERSKI, N. Pemphigus foliaceus in a barbary sheep (Ammotragus lervia). Veterinary Record, London, v. 17, n. 165, p. 509-510, 2009.

JACKSON, P. G. G.; LLOYD, S.; JEFFERIES, A. R. Pemphigus foliaceus in a goat. Veterinary Record, London, v. 114, n. 19, p. 479, 1984.

KOLOU, L.; KUSUMI, A.; STEINBERG, M. S.; KLAUS-KOVTUN, V.; STANLEY, J. R. Human autoantibodies against a desmosomal core protein in pemphigus foliaceus. Journal of Experimental Medicine, New York, v. 160, n. 5, p. 1509-1518, 1984.

LAMBACHER, B.; SCHOISWOHL, J.; BRUNTHALER, R.; WITTEK, T.; KRAMETTER-FRÖTSCHER, R. Successful treatment of pemphigus foliaceus in a Berrichon du Cher ram with methylprednisolone acetate. Veterinary Dermatology, Oxford, v. 28, n. 5, p. 499-e117, 2017.

MACÊDO, J. T. S. A.; RIET-CORREA, F.; DANTAS, A. F. M.; SIMÕES, S. V. D. Pênfigo foliáceo em cabra Boer. Ciência Rural, Santa Maria, v. 38, n. 9, p. 2633-2635, 2008.

OLIVRY, T.; LAVOY, A.; DUNSTON, S. M.; BROWN, R. S.; LENNON, E. M.; WARREN, S. J.; PRISAYANH, P.; MÜLLER, E. J.; SUTER, M. M.; DEAN, G. A. Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus. Veterinary Immunology and Immunopathology, Amsterdam, v. 110, n. 3-4, p. 245-255, 2006.

PAPPALARDO, E.; ABRAMO, F.; NOLI, C. Pemphigus foliaceus in a goat. Veterinary Dermatology, Oxford, v. 13, n. 6, p. 331-336, 2002.

SCHMIDT, E.; ZILLIKENS, D. Modern diagnosis of autoimmune blistering skin diseases. Autoimmunity Reviews, Amsterdam, v. 10, n. 2, p. 84-89, 2010.

SCOTT, D. W.; MANNING, T. O.; SMITH, C. A.; LEWIS, R. M. Pemphigus and pemphigoid in dogs, cats and horses. Annals of the New York Academy of Science, New York, v. 420, n. 1, p. 353-360, 1983.

SCOTT, D. W.; SMITH, M. C.; SMITH, C. A.; LEWIS, R. M. Pemphigus foliaceus in a goat. Agri-Practice, Santa Barbara, v. 5, n. 4, p. 38-45, 1984.

VALDEZ, R. A.; GELBERG, H. B.; MORIN, D. E.; ZUCKERMANN, F. A. Use of corticosteroids and aurothioglucose in a pygmy goat with pemphigus foliaceus. Journal of the American Veterinary Medical Association, New York, v. 207, n. 6, p. 761-765, 1995.

VANDENABEELE, S. I. J.; WHITE, S. D.; AFFOLTER, V. K.; KASS, P. H.; IHRKE, P. J. Pemphigus foliaceus in the horse: a retrospective study of 20 cases. Veterinary Dermatology, Oxford, v. 15, n. 6, p. 381-388, 2004.

VAUGHAN, D. F.; CLAY HODGIN, E.; HOSGOOD, G. L.; BERNSTEIN, J. A. Clinical and histopathological features of pemphigus foliaceus with and without eosinophilic in?ltrates: a retrospective evaluation of 40 dogs. Veterinary Dermatology, Oxford, v. 21, n. 2, p. 166-174, 2010.




DOI: http://dx.doi.org/10.5433/1679-0359.2019v40n2p1001

Semina: Ciênc. Agrár.
Londrina - PR
E-ISSN 1679-0359
DOI: 10.5433/1679-0359
E-mail: semina.agrarias@uel.br
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