Mathematical modeling of bovine brucellosis control using the RB51 vaccine

Vanessa Aparecida Feijó de Souza, José Soares Ferreira Neto, Marcos Amaku, Ricardo Augusto Dias, Evelise Oliveira Telles, José Henrique Hildebrand Grisi-Filho, Marcos Bryan Heinemann, Fernando Ferreira


The Brazilian Ministry of Agriculture, Livestock and Food Supply established the National Program for Control and Eradication of Brucellosis and Tuberculosis (PNCEBT) in 2001. One of the main strategies adopted by the program is the mandatory vaccination of heifers between three and eight months of age with the B19 strain. In 2007, Brazil allowed the use of RB51 vaccine in bovine females over 8 months of age as an option for the producer, but kept the B19 strain as a mandatory vaccine. This decision is based on the assumption that combining the two vaccines allows to achieve significant vaccination coverage sooner and, consequently, accelerates the fall speed of prevalence. Thus, this study aimed to measure the impact of the combined use of these two vaccines in reducing the prevalence, using as a tool the mathematical modeling. It was concluded that vaccination by RB51, if adopted as a complement to vaccination by B19, mean decrease in the prevalence of bovine brucellosis in less time.


Bovine brucellosis; Mathematical modeling; Vaccine; B19; RB51.

Full Text:



Semina: Ciênc. Agrár.
Londrina - PR
E-ISSN 1679-0359
DOI: 10.5433/1679-0359
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional