Uso terapêutico da associação do omeprazol com corticóide em um cão com hidrocefalia não-responsiva ao tratamento convencional

Alexandre Mendes Amude, Rosana Zanatta, Raquel de Souza Lemos, Lidiane Pelegrini, Katiuzi Quadros Alba, Fernanda Viccini, Amauri Alcindo Alfieri

Abstract


Medical therapy for hydrocephalus includes the administration of medications to limit the production of the cerebrospinal fluid (CSF) resulting in reduced intracranial pressure (ICP). This report describes the clinical findings in one dog with congenital hydrocephalus that was unresponsive to conventional medical treatment (steroids) but demonstrated good response to omeprazole when this drug was added to the steroid. Omeprazole might decrease the CSF production by about 26% according to experimental studies with healthy dogs, but the usage of the omeprazole in clinical trials with affected dogs such as hydrocephalic animals is lacking. The results of this report might suggest that omeprazole can be used added to steroids to ameliorate the neurological status in dogs with increased ICP by hydrocephalus.


Keywords


Omeprazol; Fluido cerebroespinhal; Hidrocefalia.



DOI: http://dx.doi.org/10.5433/1679-0359.2013v34n2p805

Semina: Ciênc. Agrár.
Londrina - PR
E-ISSN 1679-0359
DOI: 10.5433/1679-0359
E-mail: semina.agrarias@uel.br
Este obra está licenciado com uma Licença Creative Commons Atribuição-NãoComercial 4.0 Internacional