Stromal Cell-Derived Factor-1 chemokine genetic polymorphism in hepatitis B patients.

Autores

  • Marla Karine Amarante Universidade Estadual de Londrina
  • Carlos Eduardo Coral de Oliveira
  • Mateus Nóbrega Aoki
  • Maria Angelica Ehara Watanabe

Palavras-chave:

SDF-1?, HBV, polymorphism

Resumo

Hepatitis B virus (HBV) is noncytopathic, hepatotropic and cause acute and chronic necroinflammatory liver diseases. Many chemokine and yours receptors are involved in the HBV pathogenesis, with a role at the infection capacity and the host response. Sequence analysis of a common variant revealed a G?A transition at position 801 (counting from the ATG start codon) in the 3’ untranslated region (3’ UTR) of the reference sequence (GenBank L36033) consist the polymorphism designated SDF1-3’UTR-801 G?A and abbreviated SDF13’A which is represented in the SDF-1? but not in the SDF-1? transcript. The objective of this study was to evaluate the genotype of patients infected with HBV through a PCR-RFLP. The present study focuses the same distribution of the SDF-1 allele in the HBV positive and negative individuals. Keywords:

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Publicado

2016-02-05

Como Citar

Amarante, M. K., Coral de Oliveira, C. E., Nóbrega Aoki, M., & Ehara Watanabe, M. A. (2016). Stromal Cell-Derived Factor-1 chemokine genetic polymorphism in hepatitis B patients. Biosaúde, 12(1/2), 25–30. Recuperado de https://ojs.uel.br/revistas/uel/index.php/biosaude/article/view/24313

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