Linha de Pesquisa
Fisiologia e Fisiopatologia cardiovascular
Descrição
O interesse do laboratório de fisiologia cardiovascular está em estudar os mecanismos de controle cardiocirculatório central e periférico em animais sob condições fisiológicas como o exercício físico e mudanças posturais, bem como em modelos animais de doenças como a obesidade, a sepse, a doença de Chagas e o parkinsonismo. Para essa abordagem utilizamos técnicas de estereotaxia; registro cardiovascular invasivo e não invasivo; análise da variabilidade cardiovascular e dosagens bioquímicas em plasma e tecidos.
Principais trabalhos
Raquel HA, Masson GS, Barna BF, Zanluqui NG, Pinge-Filho P, Michelini LC, Martins-Pinge MC. Swimming Training Modulates Nitric Oxide-Glutamate Interaction in the Rostral Ventrolateral Medulla in Normotensive Conscious Rats.Front Physiol. 2016 Jun 13;7:221.
Amorim ED, Peras VR, de Andrade O, Martins-Pinge MC Functional evidence of paraventricular nucleus involvement in cardiovascular and autonomic modulation in response to acute microgravity (head-down tilt) in unanesthetized rats.. J Neurosci Res. 2015; 93(8):1305-12.
Ariza D, Sisdeli L, Crestani CC, Fazan R, Martins-Pinge MC. Dysautonomias in Parkinson's disease: cardiovascular changes and autonomic modulation in conscious rats after infusion of bilateral 6-OHDA in substantia nigra. Am J Physiol Heart Circ Physiol. 2015 Feb 1;308(3):H250-7
da Cunha NV, Pinge-Filho P, Panis C, Silva BR, Pernomian L, Grando MD, Cecchini R, Bendhack LM, Martins-Pinge MC. Decreased endothelial nitric oxide, systemic oxidative stress, and increased sympathetic modulation contribute to hypertension in obese rats.Am J Physiol Heart Circ Physiol. 2014, 15;306(10):H1472-80.
Martins-Pinge MC, Mueller PJ, Foley CM, Heesch CM, Hasser EM. Regulation of arterial pressure by the paraventricular nucleus in conscious rats: interactions among glutamate, GABA, and nitric oxide.Front Physiol. 2013;3:490
Karlen-Amarante M, da Cunha NV, de Andrade O, de Souza HC, Martins-Pinge MC. Altered baroreflex and autonomic modulation in monosodium glutamate-induced hyperadipose rats. Metabolism. 2012 Oct;61(10):1435-42.
Mastelari RB, de Souza HC, Lenhard A, de Aguiar Corrêa FM, Martins-Pinge MC.Nitric oxide inhibition in paraventricular nucleus on cardiovascular and autonomic modulation after exercise training in unanesthetized rats.Brain Res. 2011;1375:68-76
Cunha NV, de Abreu SB, Panis C, Grassiolli S, Guarnier FA, Cecchini R, Mazzuco TL, Pinge-Filho P, Martins-Pinge MC. Cox-2 inhibition attenuates cardiovascular and inflammatory aspects in monosodium glutamate-induced obese rats.Life Sci. 2010;87(11-12):375-81.
Mehanna A, Vitorino DC, Panis C, Blanco EE, Pinge-Filho P, Martins-Pinge MC. Cardiovascular and pulmonary effects of NOS inhibition in endotoxemic conscious rats subjected to swimming training. Life Sci. 2007; 81(16):1301-8.
Martins-Pinge MC, Garcia MR, Zoccal DB, Crestani CC, Pinge-Filho P. Differential influence of iNOS and nNOS inhibitors on rostral ventrolateral medullary mediated cardiovascular control in conscious rats. Auton Neurosci. 2007 Jan 30;131(1-2):65-9.
Martins-Pinge MC, Becker LK, Garcia MR, Zoccal DB, Neto RV, Basso LS, de Souza HC, Lopes OU. Attenuated pressor responses to amino acids in the rostral ventrolateral medulla after swimming training in conscious rats.Auton Neurosci. 2005;122(1-2):21-8.
Martins-Pinge MC, Araújo GC, Lopes OU. Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats.Hypertension. 1999 Oct;34(4 Pt 2):748-51
Martins-Pinge MC, Baraldi-Passy I, Lopes OU. Excitatory effects of nitric oxide within the rostral ventrolateral medulla of freely moving rats. Hypertension. 1997 Sep;30(3 Pt 2):704-7.