Linha de Pesquisa
Fisiologia Metabólica
Descrição
No Laboratório de Fisiologia Metabólica estudamos a participação do fígado na regulação da glicemia e do metabolismo energético em diferentes condições metabólicas. Estudamos também as alterações do metabolismo de carboidratos, lipídeos e proteínas em estados patológicos, como na caquexia associada ao câncer (tumor Walker-256).
Principais trabalhos
SIQUEIRA, J.T; BATISTELA, E.; PEREIRA, M.P.; DA SILVA, V.C.; DE SOUSA JUNIOR, P.T.; ANDRADE, C.M.B.; KAWASHITA, N.H.; BERTOLINI, G.L.; BAVIERA, A. M. Combretum lanceolatum flowers ethanol extract inhibits hepatic gluconeogenesis: an in vivo mechanism study. Pharmaceutical Biology,v.10, p.1-9, 2016.
PEREIRA, M.P.; BUZELLE, S.L.; BATISTELA, E.; DONEDA, D.L.; DE FRANÇA, S.A.; DOS SANTOS, M.P.; ANDRADE, C.M.B.; GARÓFALO, M.A.R.; DO C. KETTELHUT, I.; NAVEGANTES, L.C.C.; CHAVES, V.E.; BERTOLINI, G.L.; KAWASHITA, N.H. High glucose uptake in growing rats adapted to a low-protein, high-carbohydrate diet determines low fasting glycemia even with high hepatic gluconeogenesis. Canadian Journal of Physiology and Pharmacology. v.92, p.460-466, 2014.
FARIA, J.A.; KINOTE, A.; IGNACIO-SOUZA, L.M.; DE ARAUJO, T.M.; RAZOLLI, D.S.; DONEDA, D.L.; PASCHOAL, L.B.; LELLIS-SANTOS, C.; BERTOLINI, G.L.; VELLOSO, L.A.; BORDIN, S.; ANHE, G.F. Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats. AJP: Endocrinology and Metabolism. v.305, p.E230-E242, 2013.
CHAVES, V.E.; MESQUITA JÚNIOR, F.; BERTOLINI, G.L. The metabolic effects of growth hormone in adipose tissue. Endocrine. v.43, p.10.1007/s12020, 2013.
SANTOS, M.P.; FRANÇA, S.A.; SANTOS, J.T.F.; BUZELLE, S. L.; BERTOLINI, G. L.; GARÓFALO, M.A.R.; KETTELHUT, I.C.; FRASSON, D.; CHAVES, V.E.;KAWASHITA, N.H. A Low-Protein, High-Carbohydrate Diet Increases Fatty Acid Uptake and Reduces Norepinephrine-Induced Lipolysis in Rat Retroperitoneal White Adipose Tissue. Lipids. v.47, p.279-289, 2012.
BAZOTTE, R.B.; LOPES-BERTOLINI, G. Effects of oral L-carnitine and DL-carnitine supplementation on alloxan-diabetic rats. Brazilian Archives of Biology and Technology. v.55, p.81-88, 2012.
OBICI, S.; LOPES-BERTOLINI, G.; CURI, R.; BAZOTTE, R. B.Liver glycogen metabolism during short-term insulin-induced hypoglycemia in fed rats. Cell Biochemistry and Function. v.26, p.755-759, 2008.
LOPES, G.; GAZOLA, V.A.F.G.; GALENDE, S.B.; ALVES DO PRADO, W.; CURI, R.; BAZOTTE, R. B. Comparative acute effects of L-carnitine and DL-carnitine on hepatic catabolism of L-alanine and L-glutamine in rats. Acta Pharmacologica Sinica. v.25, p.1257-1261, 2004.
GAZOLA, V.A.F.G.; LOPES, G.; DIAS, R.M.M.; CURI, R.; BAZOTTE, R.B. Comparative effects of diet supplementation with L- and DL-carnitine on ammonia toxicity and hepatic metabolism in rats. Acta Pharmacologica Sinica. v.22, p.305-310, 2001.
BATISTA, M.R.; CURI, R.; LIMA, F.B.; LOPES, G.; BAZOTTE, R.B. Effect of a meal feeding schedule on hepatic glycogen synthesis and gluconeogenesis in rats. Journal of Biomedical Science. v.8, p.256-261, 2001.
AKIMOTO, L.S.; PEDRINHO, S.R.F.; LOPES, G.; BAZOTTE, R.B.Rates of hepatic gluconeogenesis in perfused liver of alloxan diabetic fed rats. Research Communications Chem Phatol Pharmacol. v.107, p.65-77, 2000.
VARDANEGA PEICHER, M.; LOPES, G.; LIMA, F.B.; CURI, R.; NAKANO, L. C.; BAZOTTE, R.B. Time sequence of changes in the responsiveness of glycogen breakdown to adrenergic agonists in perfused liver of rats with insulin-induced hypoglycemia. Brazilian Journal of Medical and Biological Research. v.33, p.805-813, 2000.
CEDDIA, R.B.; LOPES, G.; SOUZA, H.M.; MURAD, G.R.B.; WILLIAM JR, W.N.; BAZOTTE, R.B.; CURI, R. Acute effects of leptin on glucose metabolism of in situ rat perfused livers and isolated hepatocytes. International Journal of Obesity. v.23, p.1207-1212, 1999.
BORBAMURAD, G.R.; VARDANEGA PEICHER, M.; SOUZA, H.M.; LOPES, G.; FONSECA, M.H.; BAZOTTE, R.B. Hypoglycemia induced by insulin (HII) increases the hepatic capacity to produce glucose from gluconeogenic aminoacids. Acta Pharmacologica Sinica. v.20, p.1083-1086, 1999.
BORBAMURAD, G.R.; SOUZA, H.M.; LOPES, G.; FERREIRA, E.B.; DAMBROSO, D.; BAZOTTE, R.B. Changes in glycemia induced by exercise in rats: contribution of hepatic glycogenolysis and gluconeogenesis. Research Communications in Molecular Pathology and Pharmacology. v.102, p.113-123, 1998.
LOPES, G.; HELL, N.S.; LIMA, F.B.; VARDANEGA, M.; BAZOTTE, R.B.Responsiveness of glycogen catabolism to adrenergic agonists during insulin-induced hypoglycemia in rat livers. General Pharmacology. The Vascular System. v.30, p.593-599, 1998.
FERREIRA, E.B.; CEDDIA, R.B.; CURI, R.; ALONSO, M.I.C.; LOPES, G.; BAZOTTE, R.B. Swimming-exercise increases the capacity of perfused rat liver to produce urea from ammonia and L-glutamine. Research Communications in Molecular Pathology and Pharmacology. v.102, p.289-303, 1998.
SOUZA, H.M.; HELL, N.S.; LOPES, G.; BAZOTTE, R.B. Synergistic effect of counterregulatory hormones during insulin-induced hypoglycemia in rats: participation of lipolysis and gluconeogenesis to hyperglycemia. Acta Pharmacologica Sinica. v.17, p.455-459, 1996.
SOUZA, H.M.; HELL, N.S.; LOPES, G.; BAZOTTE, R.B.Effect of combined administration of counterregulatory hormones during insulin-induced hypoglycemia in rats: lipolysis mediated by a beta-adrenergic mechanism contributes to hyperglycemia. Brazilian Journal of Medical and Biological Research. v.27, p.2883-2887, 1994.